Rocaglamide and silvestrol

a long story from anti-tumor to anti-coronavirus compounds

verfasst von

Göran Schulz, Catherine Victoria, Andreas Kirschning, Eike Steinmann

Abstract

Covering: up to the beginning of 2020Many natural substances have been transformed again and again with regard to their pharmaceutical-medical potential, including new members of a growing class of natural products, the flavaglines. Important representatives are rocaglamide and silvestrol, isolated from the Aglaia species, which are highlighted here. These products started as potential anti-tumor agents five decades ago and have recently proved to be very promising antiviral agents, especially against RNA viruses. Today they are discussed as potential starting compounds for developing drug candidates and therapeutics.

Organisationseinheit(en)

Institut für Organische Chemie

Externe Organisation(en)

Ruhr-Universität Bochum

Typ

Artikel

Journal

Natural Product Reports

Band

38

Seiten

18-23

Anzahl der Seiten

6

ISSN

0265-0568

Publikationsdatum

2021

Publikationsstatus

Veröffentlicht

ASJC Scopus Sachgebiete

Wirkstoffforschung, Biochemie, Organische Chemie

Elektronische Version(en)

https://doi.org/10.1039/d0np00024h (Zugang: Geschlossen)