Rocaglamide and silvestrol

a long story from anti-tumor to anti-coronavirus compounds

authored by: Göran Schulz, Catherine Victoria, Andreas Kirschning, Eike Steinmann
Abstract: Covering: up to the beginning of 2020Many natural substances have been transformed again and again with regard to their pharmaceutical-medical potential, including new members of a growing class of natural products, the flavaglines. Important representatives are rocaglamide and silvestrol, isolated from the Aglaia species, which are highlighted here. These products started as potential anti-tumor agents five decades ago and have recently proved to be very promising antiviral agents, especially against RNA viruses. Today they are discussed as potential starting compounds for developing drug candidates and therapeutics.
Organisation(s): Institute of Organic Chemistry
External Organisation(s): Ruhr-Universität Bochum
Type: Article
Journal: Natural Product Reports
Volume: 38
Pages: 18-23
No. of pages: 6
ISSN: 0265-0568
Publication date: 2021
Publication status: Published
ASJC Scopus subject areas: Drug Discovery, Biochemistry, Organic Chemistry
Electronic version(s): https://doi.org/10.1039/d0np00024h (Access: Closed)